The intracellular targets of action of metronidazole on anaerobes are mostly unidentified. The 5-nitro group of metronidazole is lessened by metabolically Energetic anaerobes, and reports have demonstrated that the lowered method of the drug interacts with ‑bacterial DNA.
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METROGEL-VAGINAL affords minimum peak serum levels and systemic exposure (AUCs) of metronidazole as compared to 500 mg oral metro‑nidazole dosing. jne toto Whilst these decreased levels of exposure are not as likely to supply the common reactions noticed with oral metronidazole, the possibility of these as well as other reactions can't be excluded presently.
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